I have type-2 diabetes and suffered a hip fracture. Could this be a side effect of taking Actos?

It may seem incredible that a medication intended to lower blood sugar could contribute to a broken hip.

But research published in the Journal of Clinical Endocrinology & Metabolism indicated just that: bone fractures were overwhelmingly present in postmenopausal women taking Actos.

Why does Actos contribute to bone loss?

Actos’ key ingredient is a drug called pioglitazone. This drug may lower a diabetic’s blood sugar, but it also affects proteins in the body on a cellular level. In particular, it has been shown to activate a protein called the PPAR-gamma receptor, which makes the body produce osteoclasts-and it is these cells which degrade bone, making it thinner and more fragile.

The manufacturer of the drug Actos discovered this side effect in a clinical trial. In its prescribing information, the pamphlet explains that after three years 44 out of 870 female patients in the trial suffered a bone fracture due to pioglitazone. This accounts for roughly 5% of fractures in women over the age of 50, but evidence suggests that since many patients take Actos for a much longer period, the rate would increase over time.

Studies have shown an increased risk of bone problems in women using Actos, including:

• Fractures. Weakened bones are more likely to break under slight pressure. After taking Actos for an extended period, patients have reported broken bones in hands, feet, upper arms and even the spine.
• Osteoporosis. A common risk for older women, the degrading and contortion of the skeleton is even more common with prolonged exposure to Actos.
• Broken Hips. Hip fractures are a leading cause of death in the elderly. Due to advanced age and weakened immune systems, fractures can be fatal for older people in Florida-and those taking Actos may be significantly more at risk.

Unfortunately, trying to balance the bone loss effects of Actos with other medications may not be possible. From the research available, it does not seem likely that women can counteract the risk of fracture with increased use of common bone-strengthening aids, such as higher doses of calcium or vitamin D. Even more worryingly, the FDA has not recalled Actos, and many doctors are still prescribing the drug to patients with type-2 diabetes.

If you are being treated for type-2 diabetes and have suffered a fracture, a Palm Beach Actos class action attorney can discover whether you are owed compensation for your medical costs. Call Fetterman & Associates today at (866) 865-1244 to get started on your free consultation.